As 7-hydroxymitragynine (7OH) becomes more recognized for its analgesic and harm-reduction potential, users are increasingly asking a practical but critical question: Does 7OH show up on a drug test? Whether you're exploring it as a substitute for prescription opioids or simply curious about its biological footprint, this guide offers a science-based breakdown.
7-hydroxymitragynine, often referred to simply as 7OH, is a naturally occurring alkaloid found in trace amounts in the kratom plant (Mitragyna speciosa). It is considered one of the primary active components responsible for the pain-relieving and mood-elevating effects kratom users often report.
Unlike whole kratom, 7OH can be extracted or synthesized into purified tablets, capsules, or tinctures—offering a more targeted experience with greater dosage precision. Studies show 7OH is a partial μ-opioid receptor agonist, which gives it opioid-like effects without many of the respiratory depression risks associated with full agonists like morphine【NIH, PMC6598155】.
To understand whether 7OH will be detected, it helps to know the different types of drug tests commonly used:
Bottom Line: 7OH does not appear on most standard drug tests. However, it can be detected in specialized lab tests if kratom alkaloids are being screened.
While there is limited published pharmacokinetic data on 7OH, anecdotal user reports and preliminary lab studies provide some guidance:
Because 7OH is typically used at much lower doses than kratom (e.g., 2–6 mg vs. 3–8 grams), it's also believed to clear the body more quickly.
This is a common concern—especially for individuals in recovery programs or workplace drug screenings.
However, a targeted test can positively identify 7OH. If the testing lab is screening for kratom alkaloids, your use may be flagged.
Here are examples of real-world situations where 7OH might show up in lab tests:
Many clinics use advanced screening techniques to ensure compliance with prescribed medications. Some tests will screen for kratom or its metabolites—especially if the patient has a history of substance use.
Courts sometimes order comprehensive toxicology screens that include kratom-specific panels, depending on local laws.
While the Department of Defense doesn’t currently list kratom or 7OH on its banned substances list, specific contractors or agencies may request broader testing.
Tip: If you're under medical supervision or involved in legal proceedings, it’s best to disclose any supplement use, including kratom or 7OH.
In a 2019 study published in Drug Testing and Analysis, researchers developed liquid chromatography–tandem mass spectrometry (LC-MS/MS) methods for detecting 7OH and mitragynine in biological samples【PMID: 31225741】.
Though not scheduled under the U.S. Controlled Substances Act, 7OH is often treated as a derivative of kratom, which is banned in several U.S. states (e.g., Alabama, Wisconsin, Arkansas).
In places where kratom is banned, testing positive for 7OH might be used as evidence of regulatory violation, especially in court-mandated drug monitoring.
On forums like the 7OH subreddit, users frequently share their drug-testing experiences.
These testimonials highlight a major gap between user expectations and medical/legal realities.
If you plan to use 7OH while being monitored:
In casual or employment-related screenings (5 or 10-panel), 7-hydroxymitragynine will not appear.
In specialized medical or legal testing (e.g., LC-MS/MS), 7OH can be detected—particularly when kratom use is being investigated.
As awareness and usage grow, we may see more comprehensive screening panels include 7OH. Until then, transparency and caution remain your best tools.
Disclaimer: This article is for educational purposes only and does not constitute medical or legal advice. Always consult with a licensed provider before beginning or disclosing any new supplement or compound.